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Comparative side effects of NSAIDs, such as salsalate, choline magnesium trisalicylate, fenoprofen, naproxen, aspirin and indomethacin was assessed using the Stanford Toxicity Index (STI) consisting of weighted symptoms, laboratory abnormalities in 100 rheumatoid arthritis patients from out patient clinic of Seoul National University Hospital. All patients were enrolled in one physician who is recording any side-effects of drug on patient´s medical chart. Two pharmacists evaluated the randomly selected patient´s medical chart, and checked the recording of side effects, such as dizziness, pruritus, rash, edema, tinnitus, hearing difficulty, nausea, upper abdominal pain, constipation, dyspepsia, ear fullness, epigastric fullness, mild liver toxicity, hyperuricemia and headache. From the results of this study, it was found that common side effects were tinnitus, hearing difficulty and ear fullness for salsalate, gastrointestinal disturbances for choline magnesium trisalicylate, fenoprofen and naproxen, and gastrointestinal disturbances and hearing difficulty for aspirin, and headache for indomethacin. Scores of STI ranged from 0.32 for aspirin to 2.56 for salsalate. Also occurrence rate of side effects of NSAIDs was evaluated according to period of drug administration. It was noted that most of side effects were common within 1 year of drug administration, but naproxen and indomethacin had even distributional occurrence of side effects according to period of drug administration.
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